3-klór-5-hýdroxýbensósýra CAS 53984-36-4

Vörulýsing:

Vöruheiti: 3-klór-5-hýdroxýbensósýra CAS NO: 53984-36-4

Samheiti:

5-Klór-m-salisýlsýra;3-klór-5-hýdroxý BA;

Bensósýra, 3-klór-5-hýdroxý-;

GPR81 örvi, 3Cl-5OH-BA;

Efnafræðilegir eiginleikar:

Útlit: Hvítt til drapplitað duft

Greining: Stærra en eða jafnt og 99,0 prósent

Þéttleiki: 1.536 g/cm3

Suðumark: 364.805 gráður við 760 mmHg

Bræðslumark: 244.0 til 248.0 gráður

Blassmark: 174.428 gráður

Geymsluhitastig: Innsiglað í þurru, stofuhita

Leysni: DMSO: leysanlegt 15mg/ml (tær lausn)

Öryggisupplýsingar:

HS kóði: 2918290000

Varúðaryfirlýsing: P261; P280; P305 plús P351 plús P338

Merkiorð: Hætta

Tákn: GHS05, GHS07

Hættuyfirlýsing: H302; H315; H318; H335

5-Chloro-m-salicylic Acid was studied as a potential selective lactate receptor (GPR81) agonists with antilipolytic effects. GPR81, also known as hydroxycarboxylic acid receptor 1 (HCAR1), is a recently de-orphanized receptor that is activated by lactic acid (EC50 1.5 mM) but not by other hydroxycarboxylic acids. 3-chloro-5-hydroxy Benzoic Acid (3-chloro-5-hydroxy BA) is an agonist of GPR81 (EC50 = 16 μM) that is inactive against the related GPR109a (HCAR2) receptor. It is similarly effective at GPR81 receptors from a variety of mammalian species and is bioavailable, stimulating lipolysis (increased serum free fatty acids) in mice fed high fat chow for 10 weeks. 3-chloro-5-hydroxy BA, like lactate, blocks basal ghrelin secretion by primary gastric mucosal cells.

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